For the first time in history, the two teams will come into this weekend's border war as top five ranked teams, with possible national title implications leaning on the game's outcome.
At 11-0, the Kansas Jayhawks are in the midst of their best season in school history, and both teams are fighting for a Big 12 title, and a possible trip to the National Championship. At 10-1, Missouri now claims it's highest BCS ranking since Nov. 14, 1960, when the Tigers boasted a No.1 spot.
Neither team has ever won a conference title, or ever even been in contention for a national championship, but many analysts say that the winner of this game could indeed be in the BCS National Championship game.
The stakes have never been higher, and the talent showcased in the famed border war has never been greater.
Missouri quarterback Chase Daniel has led the Tigers to their first 10 win season in 47 years, and has set school records in in completions (309), passing yards (3,590) and touchdowns (30). Missouri's offense ranks fourth in the nation in yards per game (506.3) and sixth in points per game (42.5).
Daniel is backed by Missouri's star receiver, returner and runner, Jeremy Maclin, who's talent makes him jump off the field as the big play maker.
Kansas quarterback, Todd Reesing, on the other hand, has led his team to their best season ever, the nation's second highest points per game total (45.7) and the seventh most offensive yards per game (500.2). Reesing, just in his sophomore season, has set a school record, and is tied with Chase Daniel for third in the nation, with 30 touchdowns.
Reesing's best play maker, Brandon McAnderson has come from an unnoticed high school running back to a 1,000 yard rusher on one of the nation's top teams.
This weekend's game will be the 116th meeting of these intense rivals, and in a game that is always packed full of fan spirit and intense play, will be among the most important contests either school has ever been involved in. "It's a big game because we made it a big game. Kansas made it a big game," Chase Daniel told espn.com.
Both teams boast some very outstanding talents at several positions, and several top analysts believe that this year's game will come down to which team can make the fewest mistakes.
In last year's contest, Daniel and the rest of the Missouri offense dominated Kansas in a 42-17 win in Columbia, tying the series at 53 wins each, with 9 ties. This rivalry is the second most played game , and one of the most even series in college football, but the border war has never carried as much importance as this year's game does.
Missouri head coach Gary Pinkel told espn.com, "Everybody's going to remember the 2007 Missouri-Kansas game, I guarantee you that. Forever."
This year's game will be played at a sold out Arrowhead Stadium in Kansas City, Mo., at 8 p.m. on Saturday and will air nationwide on ABC.